11/22/2023 0 Comments NCH Prism Plus 10.28 instal the new![]() By utilizing a molecular framework combination approach, we combined two distinct chemical entities with proven antiviral and trypanocidal activity into a novel hybrid scaffold attached by an acetohydroxamic acid group (CH 2CONHOH), aiming at derivatives with dual activity. Consequently, the need for new revolutionary chemotherapies is urgent. Moreover, drug resistance is an emerging concern. Anti-HCV chemotherapy is associated with severe side effects and high cost, while dengue has no clinically approved therapy and antiparasitic drugs are outdated and difficult to administer. cruzi, constitute significant socioeconomic burden in sub-Saharan Africa and continental Latin America, yet drug development is under-funded. Diseases caused by tropical parasites of the Trypanosoma species, T. ![]() Infected individuals are at risk of developing chronic liver failure or haemorrhagic fever respectively, often with a fatal outcome if left untreated. Infections with Flaviviridae viruses, such as hepatitis C virus (HCV) and dengue virus (DENV) pose global health threats. ![]()
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